GLOBOMYCIN - NEW PEPTIDE ANTIBIOTIC WITH SPHEROPLAST-FORMING ACTIVITY .3. STRUCTURAL DETERMINATION OF GLOBOMYCIN

被引：48

作者：

NAKAJIMA, M ^{[1
]}

INUKAI, M ^{[1
]}

HANEISHI, T ^{[1
]}

TERAHARA, A ^{[1
]}

ARAI, M ^{[1
]}

KINOSHITA, T ^{[1
]}

TAMURA, C ^{[1
]}

机构：

[1] SANKYO CO LTD,CENT RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1978年 / 31卷 / 05期

关键词：

D O I：

10.7164/antibiotics.31.426

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation. Globomycin is a new cyclic peptide antibiotic composed of L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid. Among these components, L-allo-threonine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid are novel components from natural products. A newly developed mass analysis has been introduced for determining the diastereoisomers of allo-threonine. © 1978, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：426 / 432

页数：7

共 5 条

[1]

COREY EJ, 1975, TETRAHEDRON LETT, P2647

[2] GLOBOMYCIN - NEW PEPTIDE ANTIBIOTIC WITH SPHEROPLAST-FORMING ACTIVITY .1. TAXONOMY OF PRODUCING ORGANISMS AND FERMENTATION [J].

INUKAI, M ;

ENOKITA, R ;

TORIKATA, A ;

NAKAHARA, M ;

IWADO, S ;

ARAI, M .

JOURNAL OF ANTIBIOTICS, 1978, 31 (05) :410-420

[3] GLOBOMYCIN - NEW PEPTIDE ANTIBIOTIC WITH SPHEROPLAST-FORMING ACTIVITY .2. ISOLATION AND PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERIZATION [J].

INUKAI, M ;

NAKAJIMA, M ;

OSAWA, M ;

HANEISHI, T ;

ARAI, M .

JOURNAL OF ANTIBIOTICS, 1978, 31 (05) :421-425

[4]

NEEDLEMAN SB, 1970, PROTEIN SEQUENCE DET, P211

[5]

THENOT JP, 1972, ANAL LETT, V5, P519, DOI 10.1080/00032717208062117

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