HEMODYNAMIC-EFFECT OF THE METALLOPURPURIN SNET2 AND LIGHT ON TRANSPLANTABLE FANFT INDUCED BLADDER-TUMOR

被引：11

作者：

SELMAN, SH ^{[1
]}

QIN, BS ^{[1
]}

JAMES, HR ^{[1
]}

KECK, RW ^{[1
]}

GARBO, GM ^{[1
]}

MORGAN, AR ^{[1
]}

机构：

[1] UNIV TOLEDO,DEPT CHEM & MED CHEM,TOLEDO,OH 43606

来源：

JOURNAL OF UROLOGY | 1990年 / 143卷 / 03期

关键词：

D O I：

10.1016/S0022-5347(17)40044-9

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Changes in blood flow to transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide induced bladder tumors growing subcutaneously in the flanks of Fischer CDF (F344/CrlBR) rats were measured after photodynamic therapy with the photosensitizer tin (II) etiopurpurin dichloride using the radioactive microsphere technique. As with the other photosensitizers, hematoporphyrin derivative and chloroaluminum tetrasulfophtalocyanine, tin (II) etiopurpurin dichloride and light caused a rapid decrease in tumor blood flow in this tumor model. The decrease in blood flow occurred whether the vehicle for photosensitizer delivery was an emulsion or a liposome. Systemic heparinization of animals prior to light treatment did not alter changes in tumor blood flow.

引用

页码：630 / 633

页数：4

共 19 条

[1] RELEASE OF CLOTTING FACTORS FROM PHOTOSENSITIZED ENDOTHELIAL-CELLS - A POSSIBLE TRIGGER FOR BLOOD-VESSEL OCCLUSION BY PHOTODYNAMIC THERAPY [J].