SYNTHETIC STUDIES TOWARDS LEINAMYCIN - A CONCISE SYNTHESIS OF THE SPIRO-FUSED 1,3-DIOXO-1,2-DITHIOLANE MOIETY

被引：20

作者：

PATTENDEN, G

SHUKER, AJ

机构：

[1] Department of Chemistry, The University, Nottingham

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 45期

关键词：

D O I：

10.1016/0040-4039(91)80239-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the 1,3-dioxo-1,2-dithiolane residue (2) found in the antitumour antibiotic substance leinamycin (1) is described which features: (i) elaboration of the thiolactone (5), followed by (ii) ring opening to the thioacid (9) using H2S-Et3N and (iii) ring closure of (9) to (4) in the presence of aq. FeCl3, and finally (iv) oxidation (Scheme 1).

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页码：6625 / 6628

页数：4

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