SEMIQUANTITATIVE ANALYSIS OF IMMUNOREACTIVITIES OF TYROSINE-HYDROXYLASE AND AROMATIC L-AMINO-ACID DECARBOXYLASE IN THE LOCUS-CERULEUS OF DESIPRAMINE-TREATED MICE

被引：12

作者：

KOMORI, K

KUNIMI, Y

YAMAOKA, K

ITO, T

KASAHARA, Y

NAGATSU, I ^{[1
]}

机构：

[1] FUJITA HLTH UNIV,SCH MED,DEPT ANAT,TOYOAKE,AICHI 47011,JAPAN

[2] FUJITA HLTH UNIV,SCH MED,DEPT PSYCHIAT,TOYOAKE,AICHI 47011,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 147卷 / 02期

关键词：

ANTIDEPRESSANT DRUG; DESIPRAMINE; LOCUS-CERULEUS; CATECHOLAMINERGIC NEURON GROUP; MOUSE; IMMUNOHISTOCHEMISTRY; MICROPHOTOMETRIC ANALYSIS;

D O I：

10.1016/0304-3940(92)90594-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of antidepressant drugs on catecholaminergic neuron groups of the mouse brain was studied immunohistochemically, using a microphotometric semiquantitative method. The immunoreactive level of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) in the locus coeruleus (LC) was significantly decreased after 2 weeks of antidepressant administration. Our results suggest that long-term exposure to an antidepressant drug, desipramine, significantly affects intracellular catecholamine-synthesizing enzymes. These results may suggest some significant roles of the catecholaminergic neuronal groups to the action of the tricyclic antidepressant drugs.

引用

页码：197 / 200

页数：4

共 20 条

[1]

AMERAL DG, 1977, PROG NEUROBIOL, V9, P147

[2] EFFECTS OF LONG-TERM ADMINISTRATION OF ANTIDEPRESSANTS AND NEUROLEPTICS ON RECEPTORS IN THE CENTRAL NERVOUS-SYSTEM [J].