TREATMENT OF NIPPOSTRONGYLUS-BRASILIENSIS IN NORMAL AND SPF RATS USING TETRAMISOLE LOADED INTO ZEOLITE

被引：6

作者：

SHAKER, SK

DYER, A

STOREY, DM

机构：

[1] UNIV SALFORD,DEPT BIOL SCI,SALFORD M5 4WT,LANCS,ENGLAND

[2] UNIV SALFORD,DEPT CHEM & APPL CHEM,SALFORD M5 4WT,LANCS,ENGLAND

来源：

JOURNAL OF HELMINTHOLOGY | 1992年 / 66卷 / 04期

关键词：

NIPPOSTRONGYLUS-BRASILIENSIS; RAT; NEMATODA; TETRAMISOLE; CHEMOTHERAPY; ANTHELMINTICS; SLOW-RELEASE;

D O I：

10.1017/S0022149X00014735

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Administration to rats of tetramisole loaded into zeolite was more successful in killing adults of Nippostrongylus brasiliensis than the administration of tetramisole alone. The most successful treatment occurred in SPF (Specific Pathogen Free) rats dosed with tetramisole loaded into zeolite and no worms were present in this group at autopsy eight days post-infection. It is concluded that the slow release of drug from the zeolite matrix improved its efficacy, especially in removing worms from low-grade infections.

引用

页码：288 / 292

页数：5

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