A PROTEIN-KINASE ASSOCIATED WITH PAIRED HELICAL FILAMENTS IN ALZHEIMER-DISEASE

被引：71

作者：

VINCENT, IJ ^{[1
]}

DAVIES, P ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 07期

关键词：

ALZ-50 REACTIVE ANTIGEN; CASEIN KINASE-I; HEMIN; MICROTUBULE-ASSOCIATED PROTEINS-TAU;

D O I：

10.1073/pnas.89.7.2878

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified a protein kinase in immunoaffinity-purified preparations of paired helical filaments from brain tissue of individuals with Alzheimer disease. The kinase phosphorylates the filament proteins in vitro in a manner independent of second messenger regulation or of modulation by heparin and polyamines. Physiological concentrations of hemin, an oxidized heme porphyrin, inhibit the kinase and abolish Alz-50 immunoreactivity of the proteins. Since paired helical filaments are composed of hyperphosphorylated proteins, association of a protein kinase with the filaments provides a mechanism for abnormal processing of the proteins in disease.

引用

页码：2878 / 2882

页数：5

共 29 条

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