HETEROBIMETALLIC PT-TI COMPLEXES - POTENTIAL ANTICANCER DRUGS

被引：17

作者：

BERARDINI, M ^{[1
]}

EMGE, TJ ^{[1
]}

BRENNAN, JG ^{[1
]}

机构：

[1] RUTGERS UNIV,DEPT CHEM,PISCATAWAY,NJ 08855

来源：

INORGANIC CHEMISTRY | 1993年 / 32卷 / 12期

关键词：

D O I：

10.1021/ic00064a024

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Heterobimetallic complexes containing titanocene chloride and trans-platinum dichloride-DMSO functional groups have been prepared by bridging the metal centers with hydroxypyridine ligands, in order to explore the possibility that a chelate effect will enhance DNA-metal binding affinity and chemotherapeutic effectiveness. The structure of trans-PtCl2(DMSO)(NC5H4-2-OTi(C5H5)2Cl) has been determined; crystals are monoclinic, (Cc), with unit cell dimensions a = 6.958(2) angstrom, b = 18.047(3) angstrom, c = 33.217(5) angstrom, beta = 92.04(2)-degrees, V = 4168.5(16) angstrom3, and Z = 4 and density = 2.077 Mg m-3. Both metal coordination environments are virtually identical to related monometallic complexes.

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页码：2724 / 2728

页数：5

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