A COMPARISON OF THE INCORPORATION OF MODEL STEROIDS INTO NONIONIC MICELLAR AND MICROEMULSION SYSTEMS

被引：61

作者：

MALCOLMSON, C ^{[1
]}

LAWRENCE, MJ ^{[1
]}

机构：

[1] KINGS COLL LONDON,DEPT PHARM,MANRESA RD,LONDON SW3 6LX,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 02期

关键词：

D O I：

10.1111/j.2042-7158.1993.tb03700.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The incorporation of testosterone and two of its esters, and progesterone and one of its esters (log P(oct) varying from 3.3 to 6.9) into 2% w/w soybean oil/Brij 96 microemulsions and Brij 96 surfactant systems has been examined. Possible sites of incorporation have been investigated. The drug carrying improvement of an oil-in-water microemulsion over a micellar system appears to depend on the solubility of the drug in the dispersed oil phase and is significant only for very lipophilic drugs.

引用

页码：141 / 143

页数：3

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