REPLICATION OF DAMAGED DNA AND THE MOLECULAR MECHANISM OF ULTRAVIOLET-LIGHT MUTAGENESIS

被引:99
作者
LIVNEH, Z
COHENFIX, O
SKALITER, R
ELIZUR, T
机构
[1] Department of Biochemistry, The Weizmann Institute of Science, Rehovot
关键词
MUTAGENESIS; REPLICATION; DNA; ULTRAVIOLET; SOS; ESCHERICHIA COLI; CARCINOGENESIS;
D O I
10.3109/10409239309085136
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
On UV irradiation of Escherichia coli cells, DNA replication is transiently arrested to allow removal of DNA damage by DNA repair mechanisms. This is followed by a resumption of DNA replication, a major recovery function whose mechanism is poorly understood. During the post-UV irradiation period the SOS stress response is induced, giving rise to a multiplicity of phenomena, including UV mutagenesis. The prevailing model is that UV mutagenesis occurs by the filling in of single-stranded DNA gaps present opposite UV lesions in the irradiated chromosome. These gaps can be formed by the activity of DNA replication or repair on the damaged DNA. The gap filling involves polymerization through UV lesions (also termed bypass synthesis or error-prone repair) by DNA polymerase m. The primary source of mutations is the incorporation of incorrect nucleotides opposite lesions. UV mutagenesis is a genetically regulated process, and it requires the SOS-inducible proteins RecA, UmuD, and UmuC. It may represent a minor repair pathway or a genetic program to accelerate evolution of cells under environmental stress conditions.
引用
收藏
页码:465 / 513
页数:49
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