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ROLE OF ANGIOTENSIN-II IN EXTRACELLULAR-MATRIX AND TRANSFORMING GROWTH-FACTOR-BETA-1 EXPRESSION IN HYPERTENSIVE RATS

被引：38
作者：
OHTA, K
KIM, S
HAMAGUCHI, A
YUKIMURA, T
MIURA, K
TAKAORI, K
IWAO, H
机构：
[1] OSAKA CITY UNIV,SCH MED,DEPT PHARMACOL,ABENO KU,OSAKA 545,JAPAN
[2] OSAKA KYOIKU UNIV,DEPT HLTH SCI,OSAKA 582,JAPAN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 269卷 / 01期
关键词：
SPONTANEOUSLY HYPERTENSIVE RAT (SHR); EXTRACELLULAR MATRIX; TRANSFORMING GROWTH FACTOR BETA(1); MESSENGER-RNA; CARDIOVASCULAR SYSTEM; RENIN-ANGIOTENSIN SYSTEM;
D O I：
10.1016/0922-4106(94)90033-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The in vivo effects of alacepril (1-[(S)-3-acetylthio-2-methylpropanoyl]-L-prolyl-L-phenylalanine) an angiotensin converting enzyme inhibitor, and SC-52458 (5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol-5-ylphenyl)]pyridine), an angiotensin AT(1) receptor antagonist, were examined on the cardiac and aortic gene expressions of extracellular matrices and TGF-beta 1 in young spontaneously hypertensive rats (SHR). In SHR, types I and III collagen mRNAs were increased in the left ventricle, and in contrast, fibronectin, collagen IV, and transforming growth factor-beta 1 (TGF-beta 1> mRNAs were increased in aorta, compared with those in Wistar-Kyoto rats. All the enhanced mRNAs in both organs in SHR were significantly inhibited by the short-term treatment with the above two drugs. Thus, angiotensin AT(1) receptor may play an important role in the regulation of extracellular matrices and TGF-beta 1 expressions in SHR.
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页码：115 / 119
页数：5
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