ROLE OF GLUCOSE-INTOLERANCE IN CARDIAC DIASTOLIC FUNCTION IN ESSENTIAL-HYPERTENSION

Insulin resistance and glucose intolerance have been suggested to be involved in the pathogenesis of various cardiovascular diseases. We examined the role of glucose intolerance in cardiac performance and cardiac hypertrophy in 33 patients with essential hypertension (28 to 71 years of age, mean+/-SD: 53+/-13 years) who had never been treated. Patients with obesity (body mass index>30 kg/m(2)) or overt diabetes were excluded. Plasma glucose and insulin were measured after oral administration of 75 g glucose. The incremental areas of glucose and insulin were used as indices of glucose intolerance and insulin resistance, respectively. Patients with impaired glucose tolerance according to World Health Organization criteria (n=12) showed a significantly higher ratio of peak velocity during atrial contraction to early left ventricular filling phase (A/E ratio) than those with normal glucose tolerance (n=21) despite similar age, blood pressure, and left ventricular mass index. By regression analysis, left ventricular mass index positively correlated with systolic blood pressure (r =.392, P<.05) but not with any parameters of glucose and insulin metabolism. A/E ratio determined by a Doppler system significantly correlated with age (r=.776) and fasting and peak levels and incremental area of plasma glucose (r=.529, r=.468, and r=.634) but not with those parameters of insulin. In contrast, ejection fraction was not related to blood pressure, glucose tolerance, or insulin resistance. These results suggest that glucose intolerance does not play an important role in cardiac hypertrophy in essential hypertension but partly contributes to the cardiac diastolic dysfunction that develops early in these patients.