PHARMACOLOGY OF L-655,240 (3-[1-(4-CHLOROBENZYL)-5-FLUORO-3-METHYL-INDOL-2-YL]2,2-DIMETHYLPROPANOIC ACID) - A POTENT, SELECTIVE THROMBOXANE PROSTAGLANDIN ENDOPEROXIDE ANTAGONIST

被引：53

作者：

HALL, RA ^{[1
]}

GILLARD, J ^{[1
]}

GUINDON, Y ^{[1
]}

LETTS, G ^{[1
]}

CHAMPION, E ^{[1
]}

ETHIER, D ^{[1
]}

EVANS, J ^{[1
]}

FORDHUTCHINSON, AW ^{[1
]}

FORTIN, R ^{[1
]}

JONES, TR ^{[1
]}

LORD, A ^{[1
]}

MORTON, HE ^{[1
]}

ROKACH, J ^{[1
]}

YOAKIM, C ^{[1
]}

机构：

[1] MERCK FROSST CANADA INC, POB 1005, POINTE CLAIRE DOR H9R 4P8, QUEBEC, CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1987年 / 135卷 / 02期

关键词：

D O I：

10.1016/0014-2999(87)90611-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：193 / 201

页数：9

共 18 条

[1]

AKCASU A, 1959, ARCH INT PHARMACOD T, V122, P201

[2] PROSTAGLANDIN ENDOPEROXIDE ANALOGS WHICH ARE BOTH THROMBOXANE RECEPTOR ANTAGONISTS AND PROSTACYCLIN MIMETICS [J].

ARMSTRONG, RA ;

JONES, RL ;

MACDERMOT, J ;

WILSON, NH .

BRITISH JOURNAL OF PHARMACOLOGY, 1986, 87 (03) :543-551

[3] SOME QUANTITATIVE USES OF DRUG ANTAGONISTS [J].

ARUNLAKSHANA, O ;

SCHILD, HO .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1959, 14 (01) :48-58

[4] SYNTHESIS AND STRUCTURE OF THE PLATELET-AGGREGATION FACTOR THROMBOXANE-A2 [J].

BHAGWAT, SS ;

HAMANN, PR ;

STILL, WC ;

BUNTING, S ;

FITZPATRICK, FA .

NATURE, 1985, 315 (6019) :511-513

[5] AH23848 - A THROMBOXANE RECEPTOR BLOCKING DRUG THAT CAN CLARIFY THE PATHOPHYSIOLOGIC ROLE OF THROMBOXANE-A2 [J].

BRITTAIN, RT ;

BOUTAL, L ;

CARTER, MC ;

COLEMAN, RA ;

COLLINGTON, EW ;

GEISOW, SP ;

HALLETT, P ;

HORNBY, EJ ;

HUMPHREY, PPA ;

JACK, D ;

KENNEDY, I ;

LUMLEY, P ;

MCCABE, PJ ;

SKIDMORE, IF ;

THOMAS, M ;

WALLIS, CJ .

CIRCULATION, 1985, 72 (06) :1208-1218

[6] STUDIES ON L-640,035 - A NOVEL ANTAGONIST OF CONTRACTILE PROSTANOIDS IN THE LUNG [J].

CARRIER, R ;

CRAGOE, EJ ;

ETHIER, D ;

FORDHUTCHINSON, AW ;

GIRARD, Y ;

HALL, RA ;

HAMEL, P ;

ROKACH, J ;

SHARE, NN ;

STONE, CA ;

YUSKO, P .

BRITISH JOURNAL OF PHARMACOLOGY, 1984, 82 (02) :389-395

[7]

CHAN CC, 1984, J PHARMACOL EXP THER, V229, P276

[8] THROMBOXANE RECEPTOR ANTAGONIST PROPERTIES OF SQ-27,427 IN THE ANESTHETIZED GUINEA-PIG [J].

GREENBERG, R ;

STEINBACHER, TE ;

HARRIS, DN ;

HASLANGER, MF .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 103 (1-2) :19-24

[9] THROMBOXANE A2 MEDIATED BRONCHOCONSTRICTION IN THE ANESTHETIZED GUINEA-PIG [J].

GREENBERG, R ;

ANTONACCIO, MJ ;

STEINBACHER, T .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 80 (01) :19-27

[10] THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].

HAMBERG, M ;

SVENSSON, J ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2994-2998

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