A CONVENIENT SYNTHESIS OF 3-ARYL-1,2,4-TRIAZOLO[4,3-C]QUINAZOLINES

被引：10

作者：

ELKERDAWY, MM ^{[1
]}

ISMAIEL, AEM ^{[1
]}

GINEINAH, MM ^{[1
]}

GLENNON, RA ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,SCH PHARM,DEPT MED CHEM,RICHMOND,VA 23298

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 03期

关键词：

D O I：

10.1002/jhet.5570270304

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and characterization of several 3‐aryl‐1,2,4‐triazolo[4,3‐c]quinazolines is described. The first step comprises the condensation of aromatic aldehydes with 2‐(H or Cl)‐4‐hydrazinoquinazolines 2 to afford the corresponding hydrazones 3. The second step involves the cyclization to the title compounds 4 in bromine/acetic acid. Reaction of 4 (X = Cl) with cyclic amines gave the corresponding 5‐cyclicamino 5 or 5‐alkoxy derivatives 6. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：497 / 501

页数：5