IMAGE IMPROVEMENTS IN POSITRON-EMISSION TOMOGRAPHY DUE TO MEASURING DIFFERENTIAL TIME-OF-FLIGHT AND USING MAXIMUM-LIKELIHOOD-ESTIMATION

被引:21
作者
POLITTE, DG
机构
[1] Institute for Biomedical Computing, Biomedical Computer Laboratory, Washington University, St. Louis
基金
美国国家卫生研究院;
关键词
D O I
10.1109/23.106707
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Two distinctly different methods have been used to improve images produced in positron-emission tomography. The first method is to measure the differential time of flight of the photon pairs which are detected; the second is to use an iterative algorithm which computes maximum-likelihood estimates of radioactivity distributions. We have quantified the performance of algorithms which include neither, one or the other, or both methods of improvement by performing a repetitive simulation experiment using the Hoffman brain phantom as the underlying distribution of radioactivity. Our simulations show that all of the algorithms yield unbiased estimates of the desired image. The algorithm which computes maximum-likelihood estimates using time-of-flight information reconstructs images with the lowest variance. The algorithm which uses neither of these methods (filtered backprojection) reconstructs images with the highest variance. Copyright © 1990 by The Institute of Electrical and Electronics Engineers, Inc.
引用
收藏
页码:737 / 742
页数:6
相关论文
共 4 条
[1]  
Shepp L A, 1982, IEEE Trans Med Imaging, V1, P113, DOI 10.1109/TMI.1982.4307558
[2]   A MATHEMATICAL-MODEL FOR POSITRON-EMISSION TOMOGRAPHY SYSTEMS HAVING TIME-OF-FLIGHT MEASUREMENTS [J].
SNYDER, DL ;
THOMAS, LJ ;
TERPOGOSSIAN, MM .
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1981, 28 (03) :3575-3583
[3]   NOISE AND EDGE ARTIFACTS IN MAXIMUM-LIKELIHOOD RECONSTRUCTIONS FOR EMISSION TOMOGRAPHY [J].
SNYDER, DL ;
MILLER, MI ;
THOMAS, LJ ;
POLITTE, DG .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 1987, 6 (03) :228-238
[4]   IMAGE-RECONSTRUCTION FROM LIST-MODE DATA IN AN EMISSION TOMOGRAPHY SYSTEM HAVING TIME-OF-FLIGHT MEASUREMENTS [J].
SNYDER, DL ;
POLITTE, DG .
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1983, 30 (03) :1843-1849