L5178Y MOUSE LYMPHOMA CELL MUTATION ASSAY RESULTS WITH 41 COMPOUNDS

被引：66

作者：

MYHR, B

MCGREGOR, D

BOWERS, L

RIACH, C

BROWN, AG

EDWARDS, I

MCBRIDE, D

MARTIN, R

CASPARY, WJ

机构：

[1] NIEHS,CANC GENET & MOLEC PATHOL SECT,POB 1223,RES TRIANGLE PK,NC 27709

[2] HAZLETON LABS AMERICA INC,DEPT MOLEC & CELLULAR TOXICOL,KENSINGTON,MD

[3] INVERESK RES INT LTD,MUSSELBURGH,SCOTLAND

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1990年 / 16卷

关键词：

L51784 mouse lymphoma assay; mutation assay; rodent bioassay;

D O I：

10.1002/em.2850160506

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Forty‐one chemicals were tested for their abilities to induce trifluorothymidine resistance in L5178Y mouse lymphoma (MOLY) cells. These chemicals were included in the National Toxicology Program's evaluation of four in vitro short‐term toxicity assays for predicting carcinogenicity in the rodent bioassay. Of the 41 chemicals examined for this report, 8 were equivocal in the rodent bioassay, and 7 were questionable in‐the MOLY assay. If these chemicals are eliminated from an analysis of concordance, the remaining 26 chemicals lead to a concordance of 69% with a sensitivity of 71%. The specificity could not be determined because only two non‐carcinogens were detected. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：138 / 167

页数：30

共 11 条

[1] EVALUATION OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY - QUALITY-CONTROL GUIDELINES AND RESPONSE CATEGORIES [J].