NONSTEROIDAL ANTIINFLAMMATORY AGENTS - SYNTHESIS OF NOVEL 2-PYRAZOLYL-4(3H)-QUINAZOLINONES

被引：32

作者：

FARGHALY, AM

CHAABAN, I

KHALIL, MA

BEKHIT, AA

机构：

[1] Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 10期

关键词：

D O I：

10.1002/ardp.19903231004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four novel series of pyrazolyl‐4(3H)‐quinazolinones have been prepared through the reaction of 3‐aryl‐2‐hydrazino‐4(3H)‐quinazolinones with antipyrylazo‐derivatives of ethyl acetoacetate, acetylacetone or diethyl malonate. These series of compound are 3‐aryl‐2‐[1‐ethoxycarbonyl‐1‐(1,5‐dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl)hydrazono‐2‐propylidene]hydrazino‐4(3H)‐quinazolinones;3‐aryl‐2‐[4‐(4,5‐dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl)hydrazono‐3‐methyl‐5‐oxo‐4,5‐dihydro‐1H‐pyrazol‐1‐yl]‐4(3H) ‐quinazolinones; 3‐aryl‐2‐[4‐(1,5‐dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl)azo‐3,5‐dimethyl‐1H‐pyrazol‐1‐yl]‐4(3H)‐quinazolinones and 3‐aryl‐2‐[4‐(1,5‐dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl)hydrazono‐3,5‐dioxo‐pyrazolidin‐2‐yl]‐4(3H)‐quinazolinones. The antiinflammatory activity of some representatives of the prepared compounds was studied. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：833 / 836

页数：4

共 20 条

[1]

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[2]

BONDAVALLI F, 1988, FARMACO, V43, P1019

[3] QUINAZOLINONES .16. SYNTHESIS AND INVITRO PHARMACOLOGY OF 2-ARYL-1-([3-(IMIDAZOL-4-YL)PROPYL]-GUANIDINYLAKYL)-2,3-DIHYDRO-4(1H)-QUINAZOLINONES [J].