IN HUMANS ALL U3-GENES MAP TO CHROMOSOME-17P12-]P11, BUT IN MOUSE THE U3A AND U3B GENES ARE LOCATED ON DIFFERENT CHROMOSOMES

被引：4

作者：

MAZAN, S

MATTEI, MG

ROECKEL, N

QU, LH

BACHELLERIE, JP

机构：

[1] UNIV TOULOUSE 3,INST BIOL CELLULAIRE & GENET,BIOL MOLEC EUCARYOTE LAB,CNRS,F-31062 TOULOUSE,FRANCE

[2] HOP ENFANTS LA TIMONE,CTR GENET MED,INSERM,U242,F-13385 MARSEILLE 4,FRANCE

来源：

CYTOGENETICS AND CELL GENETICS | 1993年 / 62卷 / 04期

关键词：

D O I：

10.1159/000133476

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

U3 small nucleolar RNA, which participates in eukaryotic rRNA processing, is encoded by a small multigene family in mammals. In humans, the four to six gene copies code for an identical U3 RNA molecule; rodents, however, have two variant forms of these genes, U3A and U3B. We show that all U3 genes in humans map to a single chromosomal locus, 17p12-->p11, which corresponds exactly to the region of mouse Chromosome 11 where the four U3B genes are clustered. By contrast, in mouse the unique U3A gene copy is not linked to the U3B gene cluster but maps to another chromosome (the B2-B4 region of Chromosome 10).

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页码：203 / 206

页数：4

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