FOCAL OXYNTIC GLAND ATROPHY WITH ENDOCRINE CELL HYPERPLASIA IN ZOLLINGER-ELLISON SYNDROME DURING OMEPRAZOLE TREATMENT

被引：8

作者：

CARUANA, P

AZZONI, C

BERTELE, A

ANNIBALE, B

FRANZE, A

DELLEFAVE, G

BORDI, C

机构：

[1] UNIV PARMA, INST PATHOL ANAT, I-43100 PARMA, ITALY

[2] OSPED MAGGIORE PARMA, DIV GASTROENTEROL, PARMA, ITALY

[3] UNIV ROME LA SAPIENZA, MED CLIN 2, GASTROENTEROL SECT, I-00185 ROME, ITALY

来源：

HISTOPATHOLOGY | 1992年 / 21卷 / 04期

关键词：

STOMACH; ENDOCRINE CELLS; ZOLLINGER-ELLISON SYNDROME; ATROPHY;

D O I：

10.1111/j.1365-2559.1992.tb00407.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Development of focal gland atrophy of the oxyntic mucosa was found in two patients with the Zollinger-Ellison syndrome undergoing long-term treatment with omeprazole. The atrophic areas revealed florid proliferation of endocrine cells in the form of both intraglandular crescents and micronodular hyperplasia. This proliferation was significantly more pronounced than in the remaining non-atrophic mucosa. The possible relationship of these changes to long-standing pharmacological therapy for gastric acid suppression is discussed.

引用

页码：359 / 363

页数：5

共 23 条

[1] OMEPRAZOLE - GASTRIN AND GASTRIC ENDOCRINE CELL DATA FROM CLINICAL-STUDIES [J].