Establishment of a Molecular Genetic Map of Distal Mouse Chromosome 1: Further Definition of a Conserved Linkage Group Syntenic with Human Chromosome 1q

被引：68

作者：

Seldin, Michael F. ^{[1
]}

Morse, Herbert C. ^{[2
]}

LeBoeuf, Renee C. ^{[3
]}

Steinberg, Alfred D. ^{[4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] NIAID, Immunopathol Lab, NIH, Bethesda, MD 20892 USA

[3] Vet Adm Hosp, Los Angeles, CA 90073 USA

[4] NIAMSD, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

来源：

GENOMICS | 1988年 / 2卷 / 01期

关键词：

D O I：

10.1016/0888-7543(88)90108-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A linkage map of distal mouse chromosome 1 was constructed by restriction fragment length polymorphism analysis of DNAs from seven sets of recombinant inbred (RI) strains. The data obtained with seven probes on Southern hybridization combined with data from previous studies suggest the gene order Cfh, Pep-S/Ren-1,2, Ly-6, Lamb-2, At-3, Apoa-2/Ly-17, Spna-1. These results confirm and extend analyses of a large linkage group which includes genes present on a 20-30 cM span of mouse chromosome 1 and those localized to human chromosome 1q21-32. Moreover, the data indicate similar relative positions of human and mouse complement receptor-related genes REN, CD45, LAMB2, AT3, APOA2, and SPTA. These results suggest that mouse gene analyses may help in detailed mapping of human genes within such a syntenic group. (C) 1988 Academic Press, Inc.

引用

页码：48 / 56

页数：9

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