CRYOSURGERY OF LIVER-CANCER

被引：85

作者：

ONIK, GM

ATKINSON, D

ZEMEL, R

WEAVER, ML

机构：

[1] Division of Cryosurgery, Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, Pennsylvania

来源：

SEMINARS IN SURGICAL ONCOLOGY | 1993年 / 9卷 / 04期

关键词：

CRYOSURGERY; HEPATIC METASTASES; INTRAOPERATIVE ULTRASOUND; COLORECTAL CANCER;

D O I：

10.1002/ssu.2980090406

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cryosurgery, the in situ destruction of tissue using subzero temperatures, has been used to treat hepatic metastases. Because it is a focal treatment, cryosurgery can be used in patients with unresectable lesions due to location (next to major blood vessels) or multiplicity. In this study, 57 patients with unresectable hepatic metastases were treated with cryosurgery (with at least a 6-month follow-up). The number of lesions treated ranged from 1-16 with a mean of 4.6. Forty-three patients (73%) had bilobar disease, while 25 patients (42%) were treated with a combination of resection and cryosurgery. The disease-free survival rate (patients with normal computed tomography [CT] scans and carcinoembryonic antigen [CEA] levels) was 27% with a mean follow-up of 21 months. This is comparable to other hepatic cryosurgery studies that have found survival rates of 25-37.5%. Although the results are still short-term, this study indicates that hepatic cryosurgery offers the hope of long-term survival in patients with unresectable hepatic metastases. (C) 1993 Wiley-Liss, Inc.

引用

页码：309 / 317

页数：9

共 25 条

[1]

Boring CC, Squires TS, Tong T, Cancer statistics, CA, 42, pp. 19-38, (1992)

[2]

Foster JH, Treatment of metastatic disease of the liver: A skeptic's view, Semin Liver Dis., 4, pp. 170-179, (1984)

[3]

Gage A, Fazekas G, Riley E, Freezing injury to large blood vessels in dogs, Surgery, 61, pp. 748-754, (1967)

[4]

Onik G, Cooper C, Goldberg HI, Et al., Ultrasonic characteristics of frozen liver, Cryobiology, 21, pp. 321-328, (1984)

[5]

Onik G, Gilbert J, Hoddick W, Et al., Sonographic monitoring of hepatic cryosurgery in an experimental animal model, AJR, 144, pp. 1043-1047, (1985)

[6]

Onik G, Kane R, Steele G, Et al., Monitoring hepatic cryosurgery with sonography, AJR, 147, pp. 665-669, (1986)

[7]

Ravikumarts, Kane R, Et al., Hepatic cryosurgery with intraoperative ultrasound monitoring for metastatic colon carcinoma, Arch Surg., 122, pp. 403-409, (1987)

[8]

Charnley RM, Doran J, Morris DL, Cryotherapy for liver metastases: A new approach, Br J Surg, 76, pp. 1040-1041, (1989)

[9]

Kuramoto S, (1989)

[10]

Zhou XD, Tang ZY, Yu YQ, Ma ZC, Clinical evaluation of cryosurgery in the treatment of primary liver cancer: Report of 60 cases, Cancer, 61, pp. 1889-1892, (1988)

← 1 2 3 →