A TETRANUCLEOTIDE REPEAT MOUSE MINISATELLITE DISPLAYING SUBSTANTIAL SOMATIC INSTABILITY DURING EARLY PREIMPLANTATION DEVELOPMENT

被引：97

作者：

GIBBS, M

COLLICK, A

KELLY, RG

JEFFREYS, AJ

机构：

[1] UNIV LEICESTER, DEPT GENET, LEICESTER LE1 7RH, ENGLAND

[2] INST PASTEUR, PARIS 15, FRANCE

来源：

GENOMICS | 1993年 / 17卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1292

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The highly variable mouse minisatellite Hm-2 is located on chromosome 9 and consists of GGCA tetranucleotide repeats with alleles containing up to 5000 repeat units. This locus is unstable with a germline mutation rate to new length alleles of at least 3.6% per gamete. Hm-2 also shows substantial somatic instability, producing mutational mosaicism detectable in 20% of adult mice. Analysis of allele dosage in mice carrying somatic mutations, plus studies of mosaicism in mouse embryos and extraembryonic tissues, suggests that somatic mutant alleles preferentially arise during preimplantation development and particularly during the first two cell divisions after fertilization. © 1995 Academic Press. All rights reserved.

引用

页码：121 / 128

页数：8

共 49 条

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