NEUROKININ-A-LIKE IMMUNOREACTIVITY IN ARTICULAR AFFERENTS OF THE CAT

被引：8

作者：

HANESCH, U ^{[1
]}

HEPPELMANN, B ^{[1
]}

SCHMIDT, RF ^{[1
]}

机构：

[1] UNIV WURZBURG,INST PHYSIOL,RONTGENRING 9,W-8700 WURZBURG,GERMANY

来源：

BRAIN RESEARCH | 1992年 / 586卷 / 02期

关键词：

KNEE JOINT; DORSAL ROOT GANGLION; COLCHICINE; NEUROPEPTIDE; TACHYKININ; NOCICEPTION; NEUROKININ-A; SUBSTANCE-P;

D O I：

10.1016/0006-8993(92)91643-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dorsal root ganglion cells with axons innervating the cat's knee joint via the medial articular nerve were retrogradely labelled with Fast blue. Neurokinin A-like immunoreactivity was found in 4.5 +/- 1.1% (mean +/- S.D. of 5 nerves and 695 cells) of the articular afferents. Colchicine treatment of the ganglia increased the percentage of immunopositive cells to 8.5 + 0.7% (mean +/- S.D. of 6 nerves and 554 cells) after 3-22 h. The diameter distribution of the immunopositive somata ranged from 20 to 50-mu-m with a maximum at 26-30-mu-m. Comparing the proportions of neurokinin A-immunopositive cells with those of substance P, it can be calculated on the basis of mRNA encoding that neurokinin A is synthetized in about half of the substance P-containing primary articular afferents.

引用

页码：332 / 335

页数：4

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