THE ENDOSCOPIC APPEARANCE OF SEVERE INTESTINAL MYCOBACTERIUM-AVIUM COMPLEX INFECTION AS A COARSELY GRANULAR MUCOSA DUE TO MASSIVE INFILTRATION AND EXPANSION OF INTESTINAL VILLI WITHOUT MUCOSAL EXUDATION

被引:11
作者
CAPPELL, MS
PHILOGENE, C
机构
[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT MED,NEW BRUNSWICK,NJ 08903
[2] MAIMONDIES MED CTR,DEPT MED,DIV GASTROENTEROL,BROOKLYN,NY 11219
关键词
HUMAN IMMUNODEFICIENCY VIRUS; ACQUIRED IMMUNODEFICIENCY SYNDROME; MYCOBACTERIA; MYCOBACTERIUM AVIUM COMPLEX; MYCOBACTERIUM AVIUM INTRACELLULARE; INTESTINE; GASTROINTESTINAL ENDOSCOPY; DIARRHEA; HEMOPHILIA;
D O I
10.1097/00004836-199512000-00017
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Although Mycobacterium avium complex (MAC) is the most common opportunistic pathogen at postmortem in patients with AIDS, many cases are not recognized premortem. A patient with advanced AIDS had diarrhea, fecal occult blood, and iron deficiency anemia. Esophagogastroduodenoscopy showed an extensive coarsely granular mucosa, resistant to endoscopic irrigation and brushing, in the descending duodenum. Histologic analysis of duodenal biopsies confirmed expansion of intestinal villi due to massive villar infiltration by acid-fast bacilli and no mucosal exudation. An absence of mucosal exudation is consistent with an attenuated local immunologic response in advanced AIDS. MAC was isolated from mycobacterial culture of duodenal biopsies. The currently reported endoscopic appearance of intestinal MAC can aid in diagnosis by alerting the endoscopist to send biopsies for mycobacterial stains and cultures when MAC infection is suggested by this endoscopic appearance. However, even in the absence of endoscopically evident lesions, gastrointestinal endoscopic biopsy is appropriate to exclude occult opportunistic pathogens in an AIDS patient with wasting or significant gastrointestinal complaints, The currently reported pathologic findings show that villar engorgement and hypertrophy is a sufficient explanation for the granular endoscopic appearance of intestinal MAC and that mucosal exudation is not required to produce this appearance.
引用
收藏
页码:323 / 326
页数:4
相关论文
共 22 条
[1]  
BENSON CA, 1994, CLIN INFECT DIS S3, V18, P218
[2]   ENDOSCOPIC APPEARANCE OF A DUODENAL INFECTION BY MYCOBACTERIUM-AVIUM-INTRACELLULARE IN AIDS [J].
BOSCH, O ;
PORRES, JC ;
QUESADA, GM ;
OLIVA, H ;
CAMPOS, CG .
ENDOSCOPY, 1994, 26 (05) :506-506
[3]  
CAPPELL MS, 1992, AM J GASTROENTEROL, V87, P224
[4]  
CAPPELL MS, 1991, AM J GASTROENTEROL, V86, P1
[5]  
CAPPELL MS, 1992, AM J GASTROENTEROL, V87, P1823
[6]  
CAPPELL MS, 1992, AM J GASTROENTEROL, V87, P815
[7]   PANCREATIC-ABSCESS DUE TO MYCOBACTERIAL INFECTION ASSOCIATED WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].
CAPPELL, MS ;
JAVEED, M .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 1990, 12 (04) :423-429
[8]  
CAPPELL MS, 1991, AM J GASTROENTEROL, V86, P654
[9]   CLARITHROMYCIN THERAPY FOR BACTEREMIC MYCOBACTERIUM-AVIUM COMPLEX DISEASE - A RANDOMIZED, DOUBLE-BLIND, DOSE-RANGING STUDY IN PATIENTS WITH AIDS [J].
CHAISSON, RE ;
BENSON, CA ;
DUBE, MP ;
HEIFETS, LB ;
KORVICK, JA ;
ELKIN, S ;
SMITH, T ;
CRAFT, JC ;
SATTLER, FR ;
STOOL, EW ;
MACGREGOR, RR ;
BUEHNER, T ;
WU, AW ;
BARNES, GL ;
BECKER, R ;
URBANSKI, P ;
RICHARDSON, W ;
HAFNER, R ;
DIXON, D ;
FEIGAL, DW ;
DELLERSON, M ;
GUPTA, S ;
HENRY, D ;
SCHLAGER, S .
ANNALS OF INTERNAL MEDICINE, 1994, 121 (12) :905-911
[10]   CLARITHROMYCIN AND OTHER ANTIMICROBIAL AGENTS IN THE TREATMENT OF DISSEMINATED MYCOBACTERIUM-AVIUM INFECTIONS IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].
DAUTZENBERG, B ;
SAINTMARC, T ;
MEYOHAS, MC ;
ELIASZEWITCH, M ;
HANIEZ, F ;
ROGUES, AM ;
DEWIT, S ;
COTTE, L ;
CHAUVIN, JP ;
GROSSET, J .
ARCHIVES OF INTERNAL MEDICINE, 1993, 153 (03) :368-372