S(N)2' RING-OPENING OF AZIRIDINES BEARING AN ALPHA,BETA-UNSATURATED ESTER GROUP WITH ORGANOCOPPER REAGENTS - A NEW STEREOSELECTIVE SYNTHETIC ROUTE TO (E)-ALKENE DIPEPTIDE ISOSTERES

被引：70

作者：

FUJII, N

NAKAI, K

TAMAMURA, H

OTAKA, A

MIMURA, N

MIWA, Y

TAGA, T

YAMAMOTO, Y

IBUKA, T

机构：

[1] KYOTO UNIV,GRAD SCH PHARMACEUT SCI,KYOTO 606,JAPAN

[2] TOHOKU UNIV,DEPT CHEM,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 11期

关键词：

D O I：

10.1039/p19950001359

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regio- and stereo-selective synthesis of (E)-alkene dipeptide isosteres has been successfully achieved by exposing both (E)- and (Z)-N-(4-methylphenyl)sulfonyl-gamma,delta-epimino -alpha,beta-enoates to organocopper reagents at -78 degrees C for 30 min.

引用

页码：1359 / 1371

页数：13

共 74 条

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