INTERACTION OF ANTI-INFLAMMATORY DRUGS WITH SERUM PROTEINS ESPECIALLY WITH SOME BIOLOGICALLY ACTIVE PROTEINS

被引：344

作者：

MIZUSHIM.Y

KOBAYASH.M

机构：

[1] Department of Physical Therapy and Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Bunkyo

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / 20卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1968.tb09718.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction of clinically established anti‐inflammatory drugs with some proteins has shown these drugs to strongly inhibit heat coagulation of whole serum at a concentration attainable in the sera of patients. Phenylbutazone and sodium salicylate do not inhibit the biological activity of three biologically active and labile serum proteins, namely, necrotizing factor, heterogenous serum and complement. However, they do influence the effect of heat on these proteins. The relation between this drug action in vitro and the possible mode of action of the proteins in vivo is discussed. 1968 Royal Pharmaceutical Society of Great Britain

引用

页码：169 / &

共 13 条

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[5]