QUANTITATIVE ASSESSMENT OF ISOPRENALINE METABOLISM IN MAN

被引：25

作者：

MORGAN, CD

RUTHVEN, CRJ

SANDLER, M

机构：

[1] Bernhard Baron Memorial Research Laboratories, Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London

来源：

CLINICA CHIMICA ACTA | 1969年 / 26卷 / 03期

关键词：

D O I：

10.1016/0009-8981(69)90062-X

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Quantitative and semi-quantitative assay procedures have been devised or adapted to measure excretion of isoprenaline metabolites in human urine after isoprenaline administration. The metabolism of DL-isoprenaline in man has been studied using these methods. Metabolic inactivation appears to take place predominantly by sulphate conjugation, with a much smaller degree of O-methylation, whether the drug is given orally (sub-lingual or sustained release tablet) or by aerosol. © 1969.

引用

页码：381 / &

共 19 条

[1] ANTON AH, 1962, J PHARMACOL EXP THER, V138, P360
[2] CONWAY WD, 1966, FED PROC, V25, P623
[3] ABSORPTION AND ELIMINATION PROFILE OF ISOPROTERENOL 3 - METABOLIC FATE OF DL-ISOPROTERENOL-7-3H IN DOG
CONWAY, WD
MINATOYA, H
LANDS, AM
SHEKOSKY, JM
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (07) : 1135 - +
[4] CROUT J. RICHARD, 1961, STANDARD METHODS CLIN CHEM, V3, P62
[5] DAVIES DS, 1969, FED PROC, V28, P797
[6] GILES RE, 1967, J PHARMACOL EXP THER, V156, P201
[7] PRESENCE OF CONJUGATED ADRENALINE AND NORADRENALINE IN HUMAN BLOOD PLASMA
HAGGENDAL, J
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1963, 59 (03): : 255 - &
[8] FATE OF 3H-ISO-PROTERENOL IN RAT
HERTTING, G
[J]. BIOCHEMICAL PHARMACOLOGY, 1964, 13 (08) : 1119 - &
[9] STUDIES ON THE METABOLISM OF NOREPINEPHRINE, EPINEPHRINE AND THEIR ORTHO-METHYL ANALOGS BY PARTIALLY PURIFIED ENZYME PREPARATIONS
LEEPER, LC
WEISSBACH, H
UDENFRIEND, S
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1958, 77 (02) : 417 - 427
[10] ABSORPTION AND ELIMINATION PROFILE OF ISOPROTERENOL I
MINATOYA, H
LANDS, AM
PORTMANN, GA
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (07) : 968 - +

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