INTERLEUKIN-1-BETA AND TUMOR NECROSIS FACTOR-ALPHA SYNERGISTICALLY STIMULATE NERVE GROWTH-FACTOR (NGF) RELEASE FROM CULTURED RAT ASTROCYTES

被引：220

作者：

GADIENT, RA ^{[1
]}

CRON, KC ^{[1
]}

OTTEN, U ^{[1
]}

机构：

[1] UNIV BASEL, DEPT PHYSIOL, VESALGASSE 1, CH-4051 BASEL, SWITZERLAND

来源：

NEUROSCIENCE LETTERS | 1990年 / 117卷 / 03期

关键词：

Astrocyte; Interleukin-1; Nerve growth factor production; Tumor necrosis factor;

D O I：

10.1016/0304-3940(90)90687-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nerve growth factor (NGF) may mediate responses to brain injury. To examine regulation of NGF gene expression with respect to neural trauma we examined the effects of interleukin-1 β (IL-1β) and tumor necrosis factor-α (TNF-α) on NGF production in cultures of rat astroglial cells. Purified neocortical astrocytes in serum-free medium were treated with IL-1β, TNF-α or both. Whereas IL-1β and TNF-α alone elicited only small effects, simultaneous addition elicited within 48 h a large (3- to 6-fold) increase in NGF content in culture supernatants. Our data are consistent with a role for cytokines in NGF synthesis and release in the injured central nervous system (CNS). © 1990.

引用

页码：335 / 340

页数：6

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