CONTROLLED RELEASE BY USING POLY (METHACRYLIC ACID-G-ETHYLENE GLYCOL) HYDROGELS

被引:109
作者
PEPPAS, NA
KLIER, J
机构
[1] School of Chemical Engineering, Purdue University, West Lafayette
关键词
HYDROGELS; COMPLEXED NETWORKS; SWELLING; RELEASE;
D O I
10.1016/0168-3659(91)90044-E
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Graft copolymers of poly(ethylene glycol) with poly(methacrylic acid) were prepared by reaction of poly(ethylene glycol) methacrylate macromonomer with methacrylic acid in the presence of tetraethylene glycol dimethacrylate as a crosslinking agent. The materials were swollen in aqueous solutions with the pH ranging from 1.5 to 12.0. Dynamic swelling studies were performed. The swelling rates were lowest in copolymer networks with 1:1 ratios of ethylene oxide to methacrylic acid. These results were attributed to the combined effects of diffusion and complex dissociation during swelling. Solute release studies were carried out to investigate the effect of pH and swelling on the release behavior. Lowest solute release rates were observed in complex-forming networks, verifying the relationship between complexation, swelling and solute permeability.
引用
收藏
页码:203 / 214
页数:12
相关论文
共 30 条
[1]  
Peppas, Hydrogels in Medicine and Pharmacy, (1987)
[2]  
Hoffman, Afrassiabi, Dong, J. Controlled Release, 4, (1986)
[3]  
Gehrke, Andrews, Cussler, Chem. Eng. Sci., 41, (1986)
[4]  
Cussler, Stokar, Vaarberg, Am. Ind. Chem. Eng. J., 30, (1984)
[5]  
Horbett, Ratner, Kost, Recent Advances in Drug Delivery Systems, (1984)
[6]  
Ishihara, Kobayashi, Ishimaru, Shonohara, Polym. J., 16, (1984)
[7]  
Ishihara, Matsui, J. Polym. Sci., Polym. Lett. Ed., 24, (1986)
[8]  
Tsuchida, Abe, Interactions between macromolecules in solution and intermacromolecular complexes, Adv. Polym. Sci., 45, (1982)
[9]  
Bekturov, Bimendina, Adv. Polym. Sci., 43, (1980)
[10]  
Osada, Conversion of chemical into mechanical energy by synthetic polymers (chemomechanical systems), Adv. Polym. Sci., 82, (1987)