RAT MONOCLONAL-ANTIBODY DISTRIBUTION IN MICE - AN EPITOPE INSIDE THE LUNG VASCULAR SPACE MEDIATES VERY EFFICIENT LOCALIZATION

被引：32

作者：

KENNEL, SJ

LEE, R

BULTMAN, S

KABALKA, G

机构：

[1] WASHINGTON UNIV,ST LOUIS,MO 63130

[2] UNIV TENNESSEE,OAK RIDGE GRAD SCH BIOMED SCI,OAK RIDGE,TN 37830

[3] UNIV TENNESSEE,CTR BIOMED IMAGING,KNOXVILLE,TN 37920

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1990年 / 17卷 / 02期

关键词：

D O I：

10.1016/0883-2897(90)90147-S

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

MoAb to an epitope on lung endothelial cells accumulates rapidly in the lung resulting in localization ratios of over 100. MoAb to a macrophage antigen found in spleen and lung has maximum localization ratios of 24 and 5, respectively, while MoAb specific for a human tumor grown in nude mice has a maximum ratio of about 4. Epitope concentrations in target organs (300-600 ng/mg protein) are comparable in all three systems, indicating that the MoAb to endothelium is efficient in localization to the lung. © 1990.

引用

页码：193 / 200

页数：8

共 39 条

[1] DIFFERENTIAL EXPRESSION OF CELL-SURFACE GLYCOPROTEINS ON VARIOUS ORGAN-DERIVED MICROVASCULAR ENDOTHELIA AND ENDOTHELIAL-CELL CULTURES [J].