A NEW COUPLING REAGENT FOR PEPTIDE-SYNTHESIS - BENZOTRIAZOLYLOXY-BIS(PYRROLIDINO)-CARBONIUM HEXAFLUOROPHOSPHATE (BBC)

被引：57

作者：

CHEN, SQ

XU, JC

机构：

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 05期

关键词：

BENZOTRIAZOLYLOXY-BIS(PYRROLIDINO)-CARBONIUM HEXAFLUOROPHOSPHATE (BBC); COUPLING REAGENT; SOLUTION AND SOLID PHASE PEPTIDE SYNTHESIS; LEU-ENKEPHALIN;

D O I：

10.1016/S0040-4039(00)92333-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzotriazolyloxy-bis (pyrrolidino)-carbonium hexafluorophosphate (BBC) is found to be a new excellent coupling reagent devoid of cytotoxic by-product instead of HBTU and BOP. It has been applied in the solution and solid phase peptide synthesis.

引用

页码：647 / 650

页数：4

共 14 条

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[2] CHEN SQ, 1991, IN PRESS TETRAHEDRON
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[6] BENZOTRIAZOL-1-YL DIETHYL PHOSPHATE - A NEW CONVENIENT COUPLING REAGENT FOR THE SYNTHESIS OF AMIDES AND PEPTIDES
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CHANG, H
KO, YK
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[7] NEW COUPLING REAGENTS IN PEPTIDE CHEMISTRY
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[J]. TETRAHEDRON LETTERS, 1989, 30 (15) : 1927 - 1930
[8] MOISAND A, 1970, ANN PHARM FR, V28, P575
[9] OGURA H, 1980, TETRAHEDRON LETT, P1467
[10] OUSTRIN ML, 1972, ANN PHARM FR, V30, P685

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