BRAIN-DERIVED NEUROTROPHIC FACTOR PROTECTS AGAINST ISCHEMIC CELL-DAMAGE IN RAT HIPPOCAMPUS

被引：301

作者：

BECK, T ^{[1
]}

LINDHOLM, D ^{[1
]}

CASTREN, E ^{[1
]}

WREE, A ^{[1
]}

机构：

[1] MAX PLANCK INST PSYCHIAT,PLANEGG,GERMANY

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1994年 / 14卷 / 04期

关键词：

BRAIN-DERIVED NEUROTROPHIC FACTOR; HIPPOCAMPUS; ISCHEMIA; PROTECTION; RAT;

D O I：

10.1038/jcbfm.1994.86

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The neuroprotective action of brain-derived neurotrophic factor (BDNF) was evaluated in a rat model of transient forebrain ischemia. A continuous intraventricular infusion of BDNF for 7 days starting immediately before the onset of ischemia significantly increased the number of pyramidal cells in the vulnerable CA1 sector of the hippocampus. In situ hybridization experiments suggest the neuroprotection to be mediated via trkB - receptors in the hippocampus. The data indicate a therapeutic potential for the treatment of cerebral ischemia.

引用

页码：689 / 692

页数：4

共 25 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].