SYNTHESIS OF THE 3-HYDROXY OXIRACETAM ENANTIOMERS, POTENTIAL NOOTROPIC DRUGS

被引：7

作者：

ALMEIDA, JF

GRANDE, M

MORAN, JR

ANAYA, J

MUSSONS, ML

CABALLERO, MC

机构：

[1] Departamento de Química Orgánica, Universidad de Salamanca, E-37008 Salamanca

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(00)82227-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective synthesis of the potentially nootropic compounds 3-6 is reported. Derivative 3 was obtained from the readily available L-tartaric acid, by reduction of the imide 8 prepared with methyl glycinate. The other derivatives 4-6 were obtained from the dihydroxylactam 11. Protection of one of the hydroxyl groups and a Mitsunobu reaction or triflate displacement of the other group produces the remaining stereoisomers. Aminoderivatives 25 and 27 were obtained by displacement with sodium azide and reduction.

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页码：2483 / 2494

页数：12

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