EVIDENCE FOR LINKAGE BETWEEN A REGION ON CHROMOSOME 1P AND THE ACUTE INSULIN-RESPONSE IN PIMA-INDIANS

被引：52

作者：

THOMPSON, DB

JANSSEN, RC

OSSOWSKI, VM

PROCHAZKA, M

KNOWLER, WC

BOGARDUS, C

机构：

[1] Phoenix Epidemiology/Clin. Res. Br., NIDDKD, National Institutes of Health, Phoenix, AZ 85016

来源：

DIABETES | 1995年 / 44卷 / 04期

关键词：

D O I：

10.2337/diabetes.44.4.478

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A low acute insulin response (AIR) is a predictor of non-insulin-dependent diabetes mellitus (NIDDM) in insulin-resistant Pima Indians. We have initiated a search for regions of the genome linked with the AIR using sib-pair linkage analysis as a first step in identifying genes that are determinants of this phenotype. Eighteen short tandem-repeat polymorphisms from chromosome 1 were genotyped in over 900 Pima Indians and tested for linkage with NIDDM and in a subset of Pima Indians for linkage with ATR. The anonymous DNA marker D1S198 on chromosome 1p was linked with AIR (P = 0.000056) in 175 sib pairs from 60 families, all with normal glucose tolerance, but no linkage was observed between D1S198 and NIDDM (P = 0.44, 996 sib pairs). Additional markers genotyped on chromosome 1 did not show linkage with AIR or NIDDM. This study indicates that a locus on chromosome 1p may be a determinant of the phenotypic variation seen in the ATR.

引用

页码：478 / 481

页数：4

共 29 条

[1] PATHOGENESIS OF NIDDM - A BALANCED OVERVIEW [J].

DEFRONZO, RA ;

BONADONNA, RC ;

FERRANNINI, E .

DIABETES CARE, 1992, 15 (03) :318-368

[2]

DRACOPOLI NC, 1988, AM J HUM GENET, V43, P462

[3]

DRACOPOLI NC, 1992, SCIENCE, V258, P67

[4] LINKAGE ANALYSIS OF GLUT1 (HEPG2) AND GLUT2 (LIVER ISLET) GENES IN FAMILIAL NIDDM [J].

ELBEIN, SC ;

HOFFMAN, MD ;

MATSUTANI, A ;

PERMUTT, MA .

DIABETES, 1992, 41 (12) :1660-1667

[5] LINKAGE ANALYSIS OF INSULIN-RECEPTOR GENE IN FAMILIAL NIDDM [J].

ELBEIN, SC ;

SORENSEN, LK ;

TAYLOR, M .

DIABETES, 1992, 41 (05) :648-656

[6]

ELSTON RC, 1974, AM J HUM GENET, V26, P13

[7] MATURITY-ONSET DIABETES OF THE YOUNG (MODY) [J].

FAJANS, SS .

DIABETES-METABOLISM REVIEWS, 1989, 5 (07) :579-606

[8] THE GDB(TM) HUMAN GENOME DATA-BASE ANNO 1994 [J].

FASMAN, KH ;

CUTICCHIA, AJ ;

KINGSBURY, DT .

NUCLEIC ACIDS RESEARCH, 1994, 22 (17) :3462-3469

[9] FAMILIAL HYPERGLYCEMIA DUE TO MUTATIONS IN GLUCOKINASE - DEFINITION OF A SUBTYPE OF DIABETES-MELLITUS [J].

FROGUEL, P ;

ZOUALI, H ;

VIONNET, N ;

VELHO, G ;

VAXILLAIRE, M ;

SUN, F ;

LESAGE, S ;

STOFFEL, M ;

TAKEDA, J ;

PASSA, P ;

PERMUTT, MA ;

BECKMANN, JS ;

BELL, GI ;

COHEN, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (10) :697-702

[10] THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP [J].

GYAPAY, G ;

MORISSETTE, J ;

VIGNAL, A ;

DIB, C ;

FIZAMES, C ;

MILLASSEAU, P ;

MARC, S ;

BERNARDI, G ;

LATHROP, M ;

WEISSENBACH, J .

NATURE GENETICS, 1994, 7 (02) :246-339

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