INTERMITTENT SHEDDING OF HUMAN-IMMUNODEFICIENCY-VIRUS IN SEMEN - IMPLICATIONS FOR SEXUAL TRANSMISSION

被引：65

作者：

KRIEGER, JN

COOMBS, RW

COLLIER, AC

HO, DD

ROSS, SO

ZEH, JE

COREY, L

机构：

[1] UNIV WASHINGTON,DEPT MED & STAT,SEATTLE,WA 98195

[2] NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY

来源：

JOURNAL OF UROLOGY | 1995年 / 154卷 / 03期

关键词：

HIV; HIV SEROPOSITIVITY; SEXUALLY TRANSMITTED DISEASES; VIRAL; VIRUS SHEDDING; POLYMERASE CHAIN REACTION;

D O I：

10.1016/S0022-5347(01)66969-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: We attempt to increase our understanding of human immunodeficiency virus (HIV) shedding in semen. Materials and Methods: We followed 16 seropositive men for up to 27 months by HIV cocultivation, with a subset evaluated using the polymerase chain reaction. Results: The proportion with at least 1 HIV positive semen culture increased from 3 of 16 subjects (19%) at visit 1 to 10 (63%) by visit 5. Overall, HIV was cultured from 25 of 114 specimens (22%). Shedding was intermittent for each of the 10 men with at least 1 positive culture and seminal shedding patterns were highly variable. Conclusions: By culture and polymerase chain reaction, HIV is shed intermittently in the semen. If cultures are performed often enough most seropositive men shed HIV in the semen.

引用

页码：1035 / 1040

页数：6

共 40 条

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