ENANTIOSELECTIVITY AND REACTIVITY OF IMMOBILIZED LIPASE IN SUPERCRITICAL CARBON-DIOXIDE

被引：22

作者：

CERNIA, E ^{[1
]}

PALOCCI, C ^{[1
]}

GASPARRINI, F ^{[1
]}

MISITI, D ^{[1
]}

FAGNANO, N ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO STUDI CHIM & TECNOL SOSTANZE BIOL ATT,I-00185 ROME,ITALY

来源：

JOURNAL OF MOLECULAR CATALYSIS | 1994年 / 89卷 / 1-2期

关键词：

CARBON DIOXIDE; ENZYMES; LIPASE; SUPERCRITICAL FLUIDS;

D O I：

10.1016/0304-5102(93)E0289-S

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Some results and some general observations on the reactivity of different substrates in lipase-catalyzed reactions in supercritical carbon dioxide are reported. Chiral 1-phenylethanol, 2-octanol, 6-methyl-5-hepten-2-ol and trans-3-penten-2-ol have been prepared in high enantiomeric excess (ee > 80%) by enantioselective acetylation of the corresponding racemic alcohols using immobilized crude lipase (Pseudomonas sp. from Amano) in supercritical carbon dioxide.

引用

页码：L11 / L18

页数：8

共 6 条

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[2] CERNIA E, 1993, 2 C SUI FLUID SUP LO
[3] CERNIA E, 1990, GBF MONOGRAPHS, V16, P368
[4] ENZYME DENATURATION IN SUPERCRITICAL CO2 - STABILIZING EFFECT OF S-S BONDS DURING THE DEPRESSURIZATION STEP
KASCHE, V
SCHLOTHAUER, R
BRUNNER, G
[J]. BIOTECHNOLOGY LETTERS, 1988, 10 (08) : 569 - 574
[5] NAKAMURA K, 1985, CHEM ENG COMMUN, V45, P207
[6] EFFECT OF TREATMENT WITH SUPERCRITICAL CARBON-DIOXIDE ON ENZYMATIC-ACTIVITY
TANIGUCHI, M
KAMIHIRA, M
KOBAYASHI, T
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1987, 51 (02): : 593 - 594

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