A COMPARISON OF THE EFFECTS OF SODIUM SACCHARIN IN NBR RATS AND IN INTACT AND CASTRATED MALE F344 RATS

被引：21

作者：

GARLAND, EM ^{[1
]}

STJOHN, M ^{[1
]}

ASAMOTO, M ^{[1
]}

EKLUND, SH ^{[1
]}

MATTSON, BJ ^{[1
]}

JOHNSON, LS ^{[1
]}

CANO, M ^{[1
]}

COHEN, SM ^{[1
]}

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL,OMAHA,NE 68198

来源：

CANCER LETTERS | 1994年 / 78卷 / 1-3期

关键词：

ALPHA(2U)-GLOBULIN; SACCHARIN; RAT; PROLIFERATION; BLADDER;

D O I：

10.1016/0304-3835(94)90037-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High doses of sodium saccharin (NaSac) increase proliferation in the bladder of the rat, with a male preponderance. The possibility that alpha(2u)-globulin is involved in its mechanism of action was evaluated by feeding it at 7.5% of the diet to NCI-Black-Reiter (NBR) male rats, which do not synthesize liver-derived alpha(2u)-globulin. NaSac affected urinary parameters similarly in F344 and NBR male rats, but NBR rats consumed more water leading to greater urinary volume. NaSac produced less proliferation in NBR than in intact F344 rats, with intermediate changes in castrated F344 males, which had intermediate urinary alpha(2u)-globulin levels.

引用

页码：99 / 107

页数：9

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