BIOSYNTHESIS OF LIPOPOLYSACCHARIDE O-ANTIGENS

被引：262

作者：

WHITFIELD, C ^{[1
]}

机构：

[1] UNIV GUELPH,DEPT MICROBIOL,GUELPH,ON N1G 2W1,CANADA

来源：

TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 05期

基金：

加拿大自然科学与工程研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0966-842X(00)88917-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipopolysaccharide O antigens are important virulence determinants for many bacteria. O-antigen synthesis is an interesting problem in cell-surface assembly. There are two known assembly pathways, which differ in the cellular location of their polymerization steps and in the direction of chain polymerization. Some reactions are shared with those for other surface polymers, such as capsular polysaccharides, and may be potential targets for therapeutic intervention.

引用

页码：178 / 185

页数：8

共 53 条

[1]

McGrath, Osborn, J. Bacteriol., 173, pp. 649-654, (1991)

[2]

Mulford, Osborn, Proc. Natl Acad. Sci. USA, 80, pp. 1159-1163, (1983)

[3]

Schnaitman, Klena, Microbiol. Rev., 57, pp. 655-682, (1993)

[4]

Whitfield, Valvano, Adv. Microb. Physiol., 35, pp. 135-246, (1993)

[5]

Raetz, Annu. Rev. Biochem., 59, pp. 129-170, (1990)

[6]

Reeves, Bacterial Cell Wall, pp. 281-314, (1994)

[7]

Jiang, Et al., Mol. Microbiol., 5, pp. 695-713, (1991)

[8]

Osborn, Et al., Methods Enzymol., 28, pp. 583-601, (1972)

[9]

Meier-Dieter, Et al., J. Biol. Chem., 267, pp. 746-753, (1992)

[10]

Alexander, Valvano, Role of the rfe gene in the biosynthesis of the Escherichia coli O7-specific lipopolysaccharide and other O-specific polysaccharides containing N-acetylglucosamine., J Bacteriol, 176, pp. 7079-7084, (1994)

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