A COMPARISON OF DIRECT EFFECTS AND ADRENERGIC BLOCKING ACTIVITY OF D/L- AND D-PROPRANOLOL ON ELECTRICAL AND MECHANICAL BEHAVIOUR OF ISOLATED FROG VENTRICLE

被引：14

作者：

POLLEN, DW

SCOTT, AC

WALLACE, WFM

机构：

[1] Department of Physiology, Queen's University of Belfast, Northern Ireland

来源：

CARDIOVASCULAR RESEARCH | 1969年 / 3卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/cvr/3.1.7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Authors' Synopsis: Propranolol was found to reduce the rate of depolarization, amplitude, and duration of the action potential recorded from frog ventricular myocardium. In these respects, D-propranolol was of similar potency to D/L-propranolol. However, D/L-propranolol was much more effective than the dextro isomer in blocking the increase in rate of depolarization, amplitude, and duration of the action potential caused by adrenaline; it was also much more potent than the dextro isomer in blocking the inotropic response to adrenaline.

引用

页码：7 / +

页数：1

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