STIMULATORY EFFECT OF L-GLUTAMATE AND RELATED AMINO-ACIDS ON [DOPAMINE-H-3 RELEASE FROM RAT STRIATUM - INVITRO MODEL FOR GLUTAMATE ACTIONS

被引：328

作者：

ROBERTS, PJ

ANDERSON, SD

机构：

[1] Department of Physiology and Pharmacology, School of Biochemical and Physiological Sciences, University of Southampton, Southampton

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 05期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb11096.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The effects of l‐glutamate and a number of structural analogues on the spontaneous release of [3H]dopamine from slices of rat striatum were examined. Glutamate, and other excitatory amino acids produced a marked stimulation of [3H]DA release which was Ca2+‐dependent and unaffected by either procaine or tetrodotoxin. The glutamate‐stimulated release was abolished in kainate‐lesioned striatum. The action of glutamate was effectively antagonised by glutamamate diethylester and 2‐amino‐4‐phosphonobutyric acid, but only weakly by l‐methionine‐dl‐sulfoximine. Other proposed amino acid antagonists were inactive. The likely site of the releasing action of l‐glutamate on presynaptic sites on nigro‐striatal DA terminals is discussed. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：1539 / 1545

页数：7

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