POTENTIAL ANTICANCER AGENTS .V. NEW AROMATIC NITROGEN NUSTARDS RELATED TO 3-[N,N-BIS(2-CHLOROETHYL)AMINO]-4-METHYLBENZOIC ACID

被引：16

作者：

CAMBANIS, A

DOBRE, V

NICULESC.I

机构：

[1] Oncological Institute, Bucharest

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 01期

关键词：

D O I：

10.1021/jm00301a043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of new esters and amides of 3-[N,N-bis(2-chloroethyl)amino]-4-methylbenzoic acid is described. New nitrogen mustards, derivatives of phosphoric and sulfonic aromatic acids, are also reported. A quantitative relation between hydrolysis rate of these N-mustards and basicity of precursor amines was established. Enhancement of the hydrolysis rate due to the steric effect of o-methyl groups was pointed out. Antitumor activity was tested against Jensen sarcoma, Walker 256 carcinosarcoma, and Guerin T8 carcinoma. © 1969, American Chemical Society. All rights reserved.

引用

页码：161 / &

共 16 条

[1]

BARNARD PJ, 1965, ARCHIV ITAL PATOL CL, V8, P142

[2] CYTOTOXIC COMPOUNDS .V. DERIVATIVES OF P-(NN-DI-2-CHLOROETHYL- + OF P-)NN-DI-2-BROMOETHYL-AMINO)BENZENESULPHONIC ACID [J].

BENN, MH ;

WHITE, GR ;

OWEN, LN ;

JOHNSON, BJ ;

CREIGHTON, AM .

JOURNAL OF THE CHEMICAL SOCIETY, 1964, (SEP) :3395-&

[3]

COSTACHEL O, 1965, NOV P NAT C ONC BUCH

[4]

COSTACHEL O, 1968, ONCOL RADIOL, V7, P255

[5]

DOBRE V, PERSONAL COMMUNICATI

[6] PREPARATION OF SOME CARBOXYNITROPHENYLPHOSPHONIC ACIDS AND RELATED COMPOUNDS [J].

FREEDMAN, LD ;

DOAK, GO .

JOURNAL OF ORGANIC CHEMISTRY, 1961, 26 (06) :2082-&

[7] NITROGEN MUSTARD DERIVATIVES CONTAINING THE PHOSPHONATE GROUP [J].

KAGAN, F ;

BIRKENMEYER, RD ;

STRUBE, RE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1959, 81 (12) :3026-3031

[8]

KOSSOLAPOFF GM, 1952, J AM CHEM SOC, V74, P4119

[9]

KOSSOLAPOFF GM, 1949, J AM CHEM SOC, V71, P1876

[10]

KOSSOLAPOFF GM, 1947, J AM CHEM SOC, V69, P2020

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