CIMETIDINE AND SALBUTAMOL COMBINED INHIBITION OF GASTRIC-ACID SECRETION IN THE DOG

被引：4

作者：

MCCLOY, RF ^{[1
]}

PARMENTER, SC ^{[1
]}

BARON, JH ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG,LONDON W12 0HS,ENGLAND

来源：

DIGESTION | 1979年 / 19卷 / 05期

关键词：

D O I：

10.1159/000198385

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effects of salbutamol and cimetidine, alone and combination, on pentagastrin-stimulated gastric secretion have been studied in conscious dogs with gastric fistula. Salbutamol 20 nmol/kg/hr alone and cimetidine 4 μmol/kg/hr alone inhibited acid by up to 69%, cimetidine 8 μmol/kg/hr produced up to 87% inhibition and the combination of cimetidine 4 μmol/kg/hr and salbutamol 24 nmol/kg/hr almost totally inhibited acid (up to 99%). The pharmacokinetics of these inhibitions were studied and salbutamol and/or cimetidine caused a complex uncompetitive inhibition of penagastrin-stimulated acid. The inhibitory combination of the 2 drugs was additive.

引用

页码：340 / 345

页数：6

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