CETIRIZINE VS ASTEMIZOLE IN THE TREATMENT OF CHRONIC IDIOPATHIC URTICARIA

被引:28
作者
ALOMAR, A
DELACUADRA, J
FERNANDEZ, J
机构
[1] VALENCIA HOSP,VALENCIA,SPAIN
[2] PRINCESS HOSP,MADRID,SPAIN
关键词
Astemizole; cetirizine; chronic urticaria; erythema; oedema; pruritis; weals;
D O I
10.1177/030006059001800503
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
In a 4-week, double-blind, randomized, parallel study to compare the efficacy of cetirizine and astemizole, 47 patients with chronic idiopathic urticaria were enrolled, with 19 cetirizine- and 17 astemizole-treated patients being taken into account for final analysis. Both treatment groups were comparable at initial visit. Giant weals, weals, erythema and oedema were improved in both treatment groups after treatment for 1 – 4 weeks. Patients' evaluation using a visual analogue scale and symptom scores assessed on a four-point scale showed that the improvement was significantly better using cetirizine for weals (P = 0.04) and there was a trend (P = 0.09) in favour of cetirizine for the visual analogue scale. The number and severity of side-effects were similar in both treatment groups. © 1990, SAGE Publications. All rights reserved.
引用
收藏
页码:358 / 365
页数:8
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