LARGE-SCALE, PEG-SUPPORTED DNA-SYNTHESIS

被引：11

作者：

BONORA, GM ^{[1
]}

SCREMIN, CL ^{[1
]}

COLONNA, FP ^{[1
]}

GARBESI, A ^{[1
]}

机构：

[1] CNR,ICCEA,I-40064 OZZANO EMILIA,ITALY

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046457

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using polyethylenglycol (PEG) as soluble supporting polymer, oligonucleotides have been prepared in high yield by an easy and fast procedure. The method looks promising for rapid synthesis of grams of short oligomers at reasonable cost.

引用

页码：269 / 273

页数：5

共 16 条

[1] LIQUID-PHASE SYNTHESIS OF PEPTIDES
BAYER, E
MUTTER, M
[J]. NATURE, 1972, 237 (5357) : 512 - &
[2] HELP (HIGH-EFFICIENCY LIQUID-PHASE) NEW OLIGONUCLEOTIDE SYNTHESIS ON SOLUBLE POLYMERIC SUPPORT
BONORA, GM
SCREMIN, CL
COLONNA, FP
GARBESI, A
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (11) : 3155 - 3159
[3] BONORA GM, 1987, GAZZ CHIM ITAL, V117, P379
[4] BRANDSTETTER F, 1973, Tetrahedron Letters, V32, P2997
[5] RAPID OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS BY THE FILTRATION METHOD
CHAUDHURI, B
REESE, CB
WECLAWEK, K
[J]. TETRAHEDRON LETTERS, 1984, 25 (36) : 4037 - 4040
[6] COLONNA F, UNPUB
[7] CRAMER F, 1966, ANGEW CHEM INT EDIT, V5, P601, DOI 10.1002/anie.196606012
[8] NEW EFFECTIVE METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDES VIA PHOSPHOTRIESTER INTERMEDIATES
EFIMOV, VA
REVERDATTO, SV
CHAKHMAKHCHEVA, OG
[J]. NUCLEIC ACIDS RESEARCH, 1982, 10 (21) : 6675 - 6694
[9] RAPID SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES .4. IMPROVED SOLID-PHASE SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES THROUGH PHOSPHOTRIESTER INTERMEDIATES
GAIT, MJ
SINGH, M
SHEPPARD, RC
EDGE, MD
GREENE, AR
HEATHCLIFFE, GR
ATKINSON, TC
NEWTON, CR
MARKHAM, AF
[J]. NUCLEIC ACIDS RESEARCH, 1980, 8 (05) : 1081 - 1096
[10] GAIT MJ, 1984, OLIGONUCLEOTIDE SYNT, P108

← 1 2 →