DISTRIBUTION, CLEARANCE, AND MORTALITY OF ENVIRONMENTAL PSEUDOMONADS IN MICE UPON INTRANASAL EXPOSURE

被引：16

作者：

GEORGE, SE ^{[1
]}

KOHAN, MJ ^{[1
]}

WHITEHOUSE, DA ^{[1
]}

CREASON, JP ^{[1
]}

KAWANISHI, CY ^{[1
]}

SHERWOOD, RL ^{[1
]}

CLAXTON, LD ^{[1
]}

机构：

[1] IIT,RES INST,CHICAGO,IL 60616

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1991年 / 57卷 / 08期

关键词：

D O I：

10.1128/AEM.57.8.2420-2425.1991

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

When introduced intranasally, P. cepacia AC1100 (approximately 10(8) CFU/animal) and P. aeruginosa AC869 (approximately 10(3) CFU/animal) were readily cleared from the mouse. However, a approximately 10(7)-CFU dose of AC869 persisted for 14 days. Strain AC869 had a 50% lethal dose of 2.7 x 10(7) CFU. Slight morbidity occurred in animals treated with approximately 10(7) CFU of AC869 or approximately 10(8) CFU of AC1100.

引用

页码：2420 / 2425

页数：6

共 33 条

[1]

BESSA SM, 1974, P SOC EXP BIOL MED, V147, P701

[2] MEDIATORS OF PULMONARY INJURY INDUCED BY INHALATION OF BACTERIAL-ENDOTOXIN [J].