SEROTONIN DEPLETION CAUSES LONG-TERM REDUCTION OF EXPLORATION IN THE RAT

被引：46

作者：

LIPSKA, BK ^{[1
]}

JASKIW, GE ^{[1
]}

ARYA, A ^{[1
]}

WEINBERGER, DR ^{[1
]}

机构：

[1] NIH,CLIN PHARMACOL SECT,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 43卷 / 04期

关键词：

SEROTONIN; 5,7-DIHYDROXYTRYPTAMINE; AMPHETAMINE; FG-7142; EXPLORATION; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0091-3057(92)90510-M

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study assessed the effects of central serotonergic depletion on exploratory activity at baseline, as well as after administration of d-amphetamine or the anxiogenic beta-carboline FG-7142. Intraventricular 5,7-dihydroxytryptamine (5,7-DHT) induced an almost complete depletion of serotonin 15-hydroxytryptamine (5-HT)] in the medial prefrontal cortex, nucleus accumbens, medial corpus striatum, and hippocampus with no changes in norepinephrine, dopamine or dihydroxyphenylacetic acid concentrations. 5-HT-depleted rats demonstrated reduced spontaneous and d-amphetamine-augmented exploration 3-10 weeks postoperatively. An effect on FG-7142-induced inhibition of exploratory activity was not apparent. These data implicate 5-HT systems in the expression of different aspects of exploratory and amphetamine-augmented motor behaviors.

引用

页码：1247 / 1252

页数：6

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