HYPOTHERMIA PROTECTS ASTROCYTES DURING ISCHEMIA IN CELL-CULTURE

被引：20

作者：

SHUAIB, A

SOCHOCKA, E

CODE, W

HERTZ, L

机构：

[1] ROYAL UNIV HOSP SASKATOON,DEPT ANESTHESIA,SASKATOON S7N OXO,SASKATCHEWAN,CANADA

[2] ROYAL UNIV HOSP SASKATOON,DEPT PHARMACOL,SASKATOON S7N OXO,SASKATCHEWAN,CANADA

[3] ROYAL UNIV HOSP SASKATOON,SASKATCHEWAN STROKE RES CTR,SASKATOON S7N OXO,SASKATCHEWAN,CANADA

来源：

NEUROSCIENCE LETTERS | 1992年 / 146卷 / 01期

关键词：

ISCHEMIA; HYPOXIA; ASTROCYTE; CELL CULTURE; HYPOTHERMIA;

D O I：

10.1016/0304-3940(92)90174-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A mild decrease in temperature (2-3 degrees) can result in marked attenuation of ischemic neuronal damage in living animals. We now report the protective effects of hypothermia in an astrocyte with simulated ischemia in cell culture system. Hypothermia when used during ischemia showed significant reduction of damage. Brief episodes of post-ischemic hypothermia were not protective whereas more prolonged post-ischemic hypothermia showed moderate protection. Cell culture systems may prove to be useful tools to study the mechanisms of hypothermic protection during ischemia.

引用

页码：69 / 71

页数：3

共 24 条

[1] ULTRAPROFOUND HYPOTHERMIA WITH COMPLETE BLOOD SUBSTITUTION IN A CANINE MODEL [J].