HALOPERIDOL DELAYS VISUALLY EVOKED CORTICAL POTENTIALS BUT NOT ELECTRORETINOGRAMS IN MICE

被引：13

作者：

ADACHIUSAMI, E

IKEDA, H

SATOH, H

机构：

[1] Department of Ophthalmology, School of Medicine, Chiba University, Chiba

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1990年 / 6卷 / 03期

关键词：

D O I：

10.1089/jop.1990.6.203

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Visually evoked cortical potentials (VECPs) and electroretinograms(ERG) to flash stimulation were studied in one ICR strain mouse and 23 ICR mice, respectively. The effect of a dopamine receptor blocker, haloperidol, on both responses was investigated. Significant peak latency prolongation was found in VECPs following injection of haloperidol, while the amplitude reduction of the b-wave was found in ERG. No effect of anesthetics only on ERG was found. It has been assumed that haloperidol affects VECPs related function mainly the higher visual pathway. However, the slight decrease of the b-wave amplitude of ERG could not exclude the possibility of the toxic effect on the retina. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：203 / 210

页数：8

共 17 条

[1]

Bodis-Woolner I., Yahr M.D., Masurememnt of visual evoked potentials in Parkinson's disease, Brain, 101, pp. 661-671, (1978)

[2]

Gawel M.J., Das P., Vincent S., Rose F.C., Visual and auditory evoked responses in patients with Parkinson's disease, J. Neurol. Neurosurg. Psychiat, 44, pp. 227-232, (1981)

[3]

Kupersmith M.J., Shakin E., Siegel I.M., Lieberman A., Visual system abnormalities in patients with Parkinson's disease, Arch. Neurol, 39, pp. 284-286, (1982)

[4]

Sollazzo D., Influence of L-dopa/carbidopa on pattern reversal VEP: behavioural differences in primary and secondary Parkinsonism, Electroenceph. clin. Neurophysiol, 61, pp. 236-242, (1985)

[5]

Bhaskar P.A., Vanchilingam E., Bhaskar A., Devaprabhu A., Ganesan R.A., Effect of L-Dopa on visual evoked potential in patients with Parkinson's disease, Neurology, 36, pp. 1119-1121, (1986)

[6]

Gottlob I., Schneider E., Heider W., Skrandies W., Alteration of visual evoked potentials and electroretinogrlms in Parkinson's disease, Electroenceph. clin. Neurophysiol, 66, pp. 349-357, (1987)

[7]

Hansch E.C., Syndulko K., Cohen S.N., Galdberg Z.I., Potvin A.R., Toutellotte W.W., Cognntion in Parkinson disease: an event-related potential perspective, Ann. Neurol, 11, pp. 599-607, (1982)

[8]

Dinner D.S., Luders H., Hanson M., Lesser R.P., Klem G., Pattern evoked potentials (PEPs) in Parkinson's disease, Neurology, 35, pp. 610-613, (1985)

[9]

Ehle A.L., Stewart R.M., Lellelid N.E., Leventhal A., Normal checkerboard pattern reversal evoked potentials in Parkinsonism, Electroenceph. clin. Neurophysiol, 54, pp. 336-338, (1982)

[10]

Murayama K., Adachi-Usami E., Yamada T., Effects of L-dopa on electroretinographic responses and pattern visual evoked cortical potentials in juvenile Parkinsonism, Clin. Vision Sci, 4, pp. 265-268, (1989)

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