THE SIGNIFICANCE OF 3-O-METHYLDOPA CONCENTRATIONS IN THE CEREBROSPINAL-FLUID IN THE PATHOGENESIS OF WEARING-OFF PHENOMENON IN PARKINSONS-DISEASE

被引：36

作者：

TOHGI, H

ABE, T

KIKUCHI, T

TAKAHASHI, S

NOZAKI, Y

机构：

[1] Department of Neurology, Iwate Medical University, Morioka

来源：

NEUROSCIENCE LETTERS | 1991年 / 132卷 / 01期

关键词：

PARKINSONS DISEASE; WEARING-OFF; END-OF-DOSE DETERIORATION; DOPAMINE; 3-O-METHYLDOPA; CEREBROSPINAL FLUID;

D O I：

10.1016/0304-3940(91)90422-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We determined concentrations of 3-O-methyldopa (3-OMD), L-3,4-dihydroxyphenylalanine (L-dopa), dopamine (DA) and other related substances in the cerebrospinal fluid in patients with Parkinson's disease (PD) 15 h after L-dopa/carbidopa medication, and compared patients with and without the wearing-off phenomenon. Concentrations of 3-OMD significantly increased, and the ratio of DA to 3-OMD was significantly shifted in favor of 3-OMD in patients with the wearing-off compared with patients without the wearing-off. However, concentrations of L-dopa, DA, and homovanillic acid (HVA) were not different between the groups. These results suggest that even if 3-OMD is related to the pathogenesis of the wearing-off, it is not through competition with L-dopa for uptake into the brain, but through other unknown mechanisms within the brain.

引用

页码：19 / 22

页数：4

共 23 条

[1] PERMANENT HUMAN PARKINSONISM DUE TO 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) - 7 CASES [J].