FLUNARIZINE IN MIGRAINE - A MINIREVIEW

被引：38

作者：

LEONE, M ^{[1
]}

GRAZZI, L ^{[1
]}

LAMANTIA, L ^{[1
]}

BUSSONE, G ^{[1
]}

机构：

[1] IST NEUROCHIRURG C BESTA,CTR CEFALEE,I-20133 MILAN,ITALY

来源：

HEADACHE | 1991年 / 31卷 / 06期

关键词：

FLUNARIZINE; MIGRAINE; PROPHYLAXIS;

D O I：

10.1111/j.1526-4610.1991.hed3106388.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Flunarizine is a non-selective calcium antagonist. It distributes preferentially in the adipose tissue and passes the blood brain barrier. Numerous controlled clinical studies have established that flunarizine is efficacious in migraine prophylaxis, including double-blind studies in which the drug was compared with placebo or other antimigraine drugs. To avoid side effects a special schedule or administration is necessary. Flunarizine has no myogenic effect on smooth muscle cells of the vessles. It is said to be the only calicum antagonist able to protect brain cells against hypoxic damage. In addition, the considerable body of information which shows flunarizine capable of directly influencing the central nervous system, suggests that the drug's anti-migraine action may depend on its ability to influence central phenomena.

引用

页码：388 / 391

页数：4

共 27 条

[1] THE CLASSIFICATION OF CALCIUM-ANTAGONISTS BY THE WHO EXPERT COMMITTEE - RELEVANCE IN NEUROLOGY [J].

AGNOLI, A .

CEPHALALGIA, 1988, 8 :7-10

[2]

AMERY AK, 1988, CEPHALALGIA S8, V8, P11

[3]

BONO G, 1985, CEPHALALGIA, V5, P538

[4]

BRAUNWALD E, 1982, NEJM, V307, P1616

[5] NIMODIPINE VERSUS FLUNARIZINE IN COMMON MIGRAINE - A CONTROLLED PILOT TRIAL [J].

BUSSONE, G ;

BALDINI, S ;

DANDREA, G ;

CANANZI, A ;

FREDIANI, F ;

CARESIA, L ;

MILONE, FF ;

BOIARDI, A .

HEADACHE, 1987, 27 (02) :76-79

[6] FLUNARIZINE IN MIGRAINE PROPHYLAXIS - EFFICACY AND TOLERABILITY OF 5 MG AND 10 MG DOSE LEVELS [J].

CENTONZE, V ;

MAGRONE, D ;

VINO, M ;

CAPORALETTI, P ;

ATTOLINI, E ;

CAMPANALE, G ;

ALBANO, O .

CEPHALALGIA, 1990, 10 (01) :17-24

[7]

CERBO R, 1986, CEPHALALGIA, V6, P15, DOI 10.1046/j.1468-2982.1986.0601015.x

[8]

DOLPHIN AC, 1989, 4TH INT S CALC ANT F, P98

[9] NEURO-ENDOCRINE AND BEHAVIORAL-EFFECTS OF FLUNARIZINE IN YOUNG AND OLD RATS [J].

DRAGO, F ;

CONTINELLA, G ;

MANGANO, O ;

CANONICO, PL ;

BERNARDINI, R ;

SCAPAGNINI, U .

CEPHALALGIA, 1985, 5 :125-129

[10] SELECTIVE LOCALIZATION OF CALCIUM-BINDING PROTEIN IN HUMAN BRAIN-STEM, CEREBELLUM AND SPINAL-CORD [J].

FOURNET, N ;

GARCIASEGURA, LM ;

NORMAN, AW ;

ORCI, L .

BRAIN RESEARCH, 1986, 399 (02) :310-316

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