SYNTHESIS OF OPTICALLY PURE MECHANISM-BASED INHIBITORS OF GAMMA-AMINOBUTYRIC-ACID AMINOTRANSFERASE (GABA-T) VIA ENZYME-CATALYZED RESOLUTION

被引：35

作者：

MARGOLIN, AL

机构：

[1] Marion Merrell Dow Research Institute, Cincinnati, OH 45215

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(00)91763-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The kinetic resolution of gamma-ethynyl- ,gamma-allenyl- and gamma-vinyl GABA was accomplished by penicillin acylase-catalyzed hydrolysis of their N-phenylacetyl derivatives. The procedure employs inexpensive commercially available immobilized enzyme.

引用

页码：1239 / 1242

页数：4

共 37 条

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